[externally-managed] Error= The system-wide Python installation in Gentoo should be maintained using the system package manager (e.g. emerge). If the package in question is not packaged for Gentoo, please consider installing it inside a virtual environment, e.g.: python -m venv /path/to/venv . /path/to/venv/bin/activate pip install mypackage To exit the virtual environment, run: deactivate The virtual environment is not deleted, and can be re-entered by re-sourcing the activate file.